Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons
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چکیده
منابع مشابه
Single K ATP channel opening in response to action potential firing in mouse dentate granule neurons.
ATP-sensitive potassium channels (K(ATP) channels) are important sensors of cellular metabolic state that link metabolism and excitability in neuroendocrine cells, but their role in nonglucosensing central neurons is less well understood. To examine a possible role for K(ATP) channels in modulating excitability in hippocampal circuits, we recorded the activity of single K(ATP) channels in cell-...
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Action potentials (APs) are initiated in the proximal axon of most neurons. In myelinated axons, a 50-times higher sodium channel density in the initial segment compared to the soma may account for this phenomenon. However, little is known about sodium channel density and gating in proximal unmyelinated axons. To study the mechanisms underlying AP initiation in unmyelinated hippocampal mossy fi...
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ژورنال
عنوان ژورنال: Hippocampus
سال: 2009
ISSN: 1050-9631,1098-1063
DOI: 10.1002/hipo.20667